DNM1L and Alzheimer disease: In a healthy state, Drp1 is important for mitochondrial division, distribution, and synaptic functions; In AD, abnormal interactions of Drp1 with Aβ and P-tau enhance the GTPase activity of Drp1, increasing mitochondrial fragmentation, impairing healthy mitochondrial dynamics, and ultimately leading to defective mitophagy and synaptic dysfunction in AD [57].