Dysfunctional mitochondria produce higher levels of reactive oxygen species, and the interactions of Aβ and P-tau with the mitochondrial proteins Drp1, VDAC, CypD, ABAD, PINK1, and Parkin enhance mitochondrial fragmentation and reduce mitophagy, leading to defective mitochondria in AD. Here, HSD17B10 is linked to Alzheimer disease.