Considering the conflicting evidence on the effect of red meat consumption on inflammation, besides the limited number of studies on the modulatory effect of TCF7L2 rs7903146 polymorphism on the relationship between diet and inflammation, the primary outcome of this randomized controlled trial was to investigate the effect of replacing red meat with legumes in the Dietary Approach to Stop Hypertension (DASH) diet on hs-CRP over 16 weeks in overweight and obese individual with type 2 diabetes. This evidence concerns the gene TCF7L2 and type 2 diabetes mellitus.