SLC25A18 and gastric cancer: Given that GC has been demonstrated to display distinct histopathological subtypes [3], we chose PDOs derived from patients with three representative types of GC (GC2, intestinal gastric carcinoma; GC3, mixed gastric carcinoma; and GC5, gastric signet-ring cell carcinoma) and investigated the histopathological consistency of these PDOs with their primary tumors.