On the other hand, although pioglitazone inhibits aromatase expression by inhibiting proinflammatory prostaglandin E2 signaling and upregulating tumor-suppressor gene BRCA1 [21], it does not inhibit mammary tumor growth induced by N-methyl-N-nitrosourea in Sprague-Dawley rats fed a high-fat diet [22]. This evidence concerns the gene CYP19A1 and breast cancer.