Moreover, IL-10+ and IL35+ Tregs cooperatively limited the anti-tumor immune response by Blimp-1-mediated exhaustion of tumor-infiltrating T cells and upregulation of immune checkpoints, including PD-1, TIM-3, lymphocyte activation gene 3 (LAG-3), T cell immunoglobulin and immunoreceptor tyrosine-based inhibitory motif domain (TIGIT) [322]. The gene discussed is TIGIT; the disease is neoplasm.