TANs have N1 (anti-tumor) and N2 (tumor-promoting) phenotypes: N1-TANs are marked by CD11b+Ly6G+CD54+CD16+CD170low and CD177+ in mice; However, N2-TANs is characterized by CD11b+Ly6G+PD-L1+CD170high. The gene discussed is CD274; the disease is neoplasm.