The mean gestational age at the time of the peak insulin dose in women with DIP was 32 weeks, and this parameter did not significantly differ between the PGDM and GDM groups, indicating that in both groups, insulin resistance was most obvious during the period of rapid fetal development, and it was necessary to adjust the dose of insulin in a timely manner to maintain a stable blood glucose level. The gene discussed is INS; the disease is gestational diabetes.