CCL5 or RANTES (Regulated on Activation, Normal T Cell Expressed and Secreted), which we found to be 4-fold downregulated in hPARG-expressing cells, has been reported to recruit mast cells, T-cells, eosinophils, and monocytes to the tumor microenvironment as well as to promote the proliferation of tumor cells, and to induce tumor cell invasion and migration by upregulating the production of matrix degrading proteins and integrins [90]. The gene discussed is CCL5; the disease is neoplasm.