Based on the results of this work, we propose that, although the crosstalk between PARP and PARG in tumorigenesis and the genetic mechanisms by which poly(ADP-ribosyl) ation exerts its effect on a subset of genes are not yet fully understood, upregulation of PARG’s activity may be a potentially useful and unexplored avenue in the development of cancer treatment. Here, PARP1 is linked to cancer.