In support of previously published data that the increase in ADGRG1/GPR56 expression suppresses angiogenesis in melanoma tumors [99], our data demonstrate that pADPr pathway positively regulates ADGRG1 in highly proliferative cells, and suggest that hPARG may suppress angiogenesis and contribute to a reduction of tumor size and progression due to its opposite to PARP effect on pADPr moieties and ADGRG1/GPR56 in particular. This evidence concerns the gene PARP1 and melanoma.