Despite this study not being able to reveal a relationship between FGFR2 and HER2 expression, it would be valuable to consider re-testing FGFR2 expression in tumor tissues of patients after HER2-targeted therapy to analyze the relationship between FGFR2 expression changes after HER2-targeted therapy and drug resistance, because studies have indicated the role of FGFR2 in HER2-targeted lapatinib resistance [17, 18]. This evidence concerns the gene ERBB2 and neoplasm.