MAPT and Alzheimer disease: Such a Tau-induced expression of TEs, mostly long interspersed nuclear elements (LINEs) and human endogenous retroviruses (HERVs), has been associated with cognitive decline in manifest AD, in association with increased neurofibrillary tangles (NFTs) found in post-mortem AD brains, and in support of a proposed pathogenic role of TEs in neurodegeneration [101].