Based on this, p53-dependent expression of lincRNA-p21 was reported to downregulate miR-17-5p in vascular smooth muscle cells (VSMCs), thereby upregulating SIRT7 which, in turn, enhances activation of the WNT/β-catenin pathway and protects against atherosclerosis progression [113, 114]. This evidence concerns the gene CDKN1A and atherosclerosis.