In hepatocellular carcinoma, SIRT7 is overexpressed due to transcriptional repression of miR-125a-5p, miR-125b and miR-526b through promoter methylation and also due to overexpression of circPVT1 which sponges miR-3666 [121, 133, 134]. Here, SIRT7 is linked to hepatocellular carcinoma.