Prior proteomics studies also showed a decrease in proteins uromodulin (UROM), kininogen-1 (KNG1), basement membrane-specific heparan sulfate proteoglycan core protein (PGBM), and nidogen-1 (NID1) in the urine of IC/BPS patients relative to controls21,22. The gene discussed is SDC2; the disease is Bartsocas-Papas syndrome 1.