Treatment of patients with dwarfism metaphyseal chondrodysplasia Schmid type (MCDS), characterized by the accumulation of misfolded collagen X on the ER that affects cell differentiation and bone growth, with Carbamazepine promotes an increase of proteolysis and degradation of misfolded COL10A1/collagen X. An animal model of MCDS suggest that carbamazepine treatment has an impact on the alternative-splicing pre-mRNA of the unfolded protein response effector XBP1 (X-box binding protein 1)154. This evidence concerns the gene XBP1 and Severe short stature.