U2AF1 mutations lead to impaired autophagy due to aberrant ATG7 pre-mRNA processing, which was confirmed in MDS patient cells carrying the U2AF1 mutations S34F, S34Y or Q157P, which showed increased use of the distal cleavage and polyadenylation (CP) site in the ATG7 transcript118. The gene discussed is ATG7; the disease is myelodysplastic syndrome.