FOXO1 and lung adenocarcinoma: SRSF3 inhibits the expression of the transcription factors RELA/p65 (RELA proto-oncogene, NF-kB subunit) and FOXO1 (forkhead box O1), and in turn of their downstream target gene BECN1 (beclin 1) Similarly, in lung adenocarcinoma cells, SRSF1 inhibits autophagosome formation by targeting the BECN1-containing complex26.