Interestingly, this degenerative disease is characterized by mutations in other core spliceosome components including PRPF6, PRPF31, and SNRNP200 (small nuclear ribonucleoprotein U5 subunit 200)131–133 whose downregulation is also connected to ULK1 mRNA mis-splicing and mitophagy defects22. This evidence concerns the gene SNRNP200 and neurodegenerative disease.