Interestingly, the absence of Cys44 in ATG10S appears to be key for its translocation into the nucleus and recruitment to the promoter of IFNL2/IL28A (interferon lambda 2), a gene that codes for a cytokine responsible for controlling viral infections and replication but that also might mediate the fusion of the autophagosome and lysosome via direct interaction with ATG10S82. The gene discussed is IFNL2; the disease is viral infectious disease.