Regardless of the findings that revealed SETD2-mediated regulation of autophagy via ATG12, it would of interest to have additional research focused on the potential regulation of other autophagy-related gene isoforms as well as potential regulators by SETD2 not only in ccRCC, but also in other types of cancer or neurodegenerative diseases. The gene discussed is SETD2; the disease is neurodegenerative disease.