In the absence of HDLBP, a high number of mRNAs was found to be up (n = 1039) and downregulated (n = 700), suggesting that HDLBP has a great impact on gene expression, presumably due to substantially impaired cell signaling and tumor-stroma cross-talk (Supplementary Fig. 7e and Supplementary Data 8). Here, HDLBP is linked to neoplasm.