A single-cell dataset from cutaneous aGHVD has not currently been published; therefore, in order to understand how alterations in dermal macrophages could impact on local Treg function, we reasoned that investigation of the homologous CD11c+CD14+ monocyte cell interaction pathways in healthy and psoriatic skin would provide some insight into potentially similar pathways in the context of GVHD. The gene discussed is ITGAX; the disease is graft versus host disease.