Moreover, following infection in the lung, there may be a window of time in which the presence of local pro-inflammatory monocyte-derived macrophages is beneficial, as recently demonstrated in work from the Wack lab showing that influenza elicits IL-6-producing monocyte-derived alveolar macrophages that are protective against bacterial super-infection (Aegerter et al., 2020). The gene discussed is IL6; the disease is influenza.