While we did not observe an association between the frequencies of antigen-specific populations (e.g., ASCs or HLA-DR+CD38+ CD8+ T cells) at the acute time point and the level of ZIKV neutralizing antibody titers at 6 months post-infection (Figures S5E and S5F), we did find unique sets of features associated with high versus low levels of ZIKV neutralizing antibody titers. This evidence concerns the gene CD8A and infection.