The genomic profile of SCLC includes nearly ubiquitous genetic loss of TP53 and RB1 and thus the loss of G1/S cell-cycle checkpoint control in response to DNA damage (Sen et al., 2018; Rudin et al., 2012; George et al., 2015; Alexandrov et al., 2013). The gene discussed is RB1; the disease is small cell lung carcinoma.