CD8A and neoplasm: Because we have shown that TCR clones in BrMs are phenotypically restricted—that is, cells expressing a single TCR are predominately within scRNA-seq metaclusters A/D or B/C but not both (Figures 4E, 4F, and 7A)—localization of TCRs within the tumor would allow for visualization of specific CD8+ T cell phenotypes within the tumor.