UTI treatment markedly increased the neurological score, alleviate the brainedema, decreased the inflammatory cytokine TNF-α, interleukin‐1β (IL‐1β),IL‐6, NF‐κB levels, and RIP1/RIP3, which indicated that UTI-mediatedinhibition of neuroinflammation, and necroptosis alleviated neuronal damageafter ICH. The gene discussed is NFKB1; the disease is bacterial urinary tract infection.