Identifying the relative contributions of innate signaling pathways to the induction of type I IFNs and subsequent control of viral infection has important consequences in terms of understanding human susceptibility to RVFV infection, as polymorphisms in TLR3, TLR7, their respective downstream signaling adaptors TRIF and MyD88, as well as RIG-I and MAVS have all been associated with severe disease/neuropathology in humans [31]. This evidence concerns the gene RIGI and viral infectious disease.