Similar Th-associated cytokine response profiles were also found in the egg/IL-12-sensitized iNOS-KO mice, while there was little or no significant effect on the Th2 or Th1-type cytokine polarization during the natural course of infection with S. mansoni in the iNOS-KO mice versus WT mice, given the low expression of iNOS detected in infected mice [43]. Here, NOS2 is linked to infection.