It was suggested that upregulation of circPSMC3 overcame the resistance of gefitinib-resistant esophageal SCC cells to gefitinib by modulating the miR-10a-5p/PTEN axis, which provides a new therapeutic strategy for overcoming gefitinib resistance in esophageal SCC [43]. This evidence concerns the gene PTEN and esophageal squamous cell carcinoma.