Early human trials of insertion of the CYP21A gene into the genome through adenovirus transfection are underway, offering potential for long term amelioration of cortisol and aldosterone deficiency and relief of hyperandrogenism in patients with the commonest form of CAH, 21-hydroxylase deficiency, the commonest cause of AI young people (https://adrenastx.com/). The gene discussed is ENSG00000290788; the disease is classic congenital adrenal hyperplasia due to 21-hydroxylase deficiency.