Analyses of mutations [59] and mRNA expression [60, 61] patterns in adrenocortical carcinoma (ACC) have identified disturbances in FGFR cascade with a range of 0% (for FGFR1) to 6% (for FGFR4) of cases [62]. The gene discussed is FGFR1; the disease is adrenal cortex carcinoma.