Another interesting point is that many of the triphosphate metabolites of these nucleoside analogues can also allosterically activate SAMHD1 at the AS2 site [14, 143, 144, 145, 148, 149], but the biological relevance in cancer cells, if any, has been little explored/observed, perhaps owing to basal dNTPs already being sufficient for tetramerisation, which is known to be long‐lived [104]. This evidence concerns the gene SAMHD1 and cancer.