Of course, without thorough characterisation of these mutants assessing their impact upon the various biochemical/biological activities of SAMHD1 (i.e. dNTP hydrolase, nuclease recruitment, innate immunity suppression, nucleic acid binding), it is difficult to hypothesise the outcome for cancer biology, given the impact of the loss of SAMHD1 can be hypothesised to have different outcomes depending upon the biological role in question. This evidence concerns the gene SAMHD1 and cancer.