A recent sub-analysis of the FIDELIO-CKD, performed in 259 (4.6%) out of 5,674 patients taking an SGLT2i at baseline, showed a significant reduction in urine albumin-to-creatinine ratio and in renal and cardiovascular outcomes versus placebo, irrespective of the use of SGLT2i at baseline. This evidence concerns the gene ALB and chronic kidney disease.