VEGF and VEGF receptors are essential factors in the maintenance of the glomerular barrier structure, and when these are blocked, the barrier function is disrupted and proteins leak into the urine.[11] Additionally, renal function in patients with HCC has also been shown to affect prognosis.[12,13] In recent years, the prognosis of HCC patients has been prolonged, and the duration of systemic therapy tends to be long due to the influence of sequential therapy.[14] Therefore, the effects of systemic therapy on proteinuria and renal function are important in long-term treatments. This evidence concerns the gene VEGFA and hepatocellular carcinoma.