We first evaluated the diagnostic value of the recombinant PLC (rPLC) and surface-extract TLR2 activators-enriched fraction (TLR2eF) IgA ELISAs by analyzing the sera of 59 CF patients NTM-infected to the sera of 114 CF patients NTM-non-infected or a control group (31 healthy controls [HC] non-CF). This evidence concerns the gene TLR2 and cystic fibrosis.