This would result in an accumulation in TGs in intestine of keratinocyte-rescued Fatp4-null mice fed Western diet [123] and intestine-specific Fatp4-deficient mice [127], as well as an increase in neutral lipids in the skin of Fatp4-null mice [76,79] and IPS patients [75]. This evidence concerns the gene SLC27A4 and ichthyosis prematurity syndrome.