IL6 and COVID-19: In this study, we (i) globally profiled the stability of 25 proteins (out of 29 total predicted proteins) encoded by SARS-CoV-2, (ii) identified that the labile SARS-CoV-2-encoded proteins were degraded mainly through the ubiquitin-proteasome pathway, (iii) determined that the stable proteins of SARS-CoV-2 corresponded to higher levels of IgG production, and (iv) determined that SARS-CoV-2-specific antibodies were correlated with the proinflammatory mediator IL-6 in COVID-19 patients.