TPMT and acute lymphoblastic leukemia: Controversial results were reported in Asian populations: Kim et al. [60] did not find a difference in the cumulative incidence of grade III/IV febrile neutropenia according to ITPA genotypes in Korean ALL pediatric patients whereas Malaysian patients with ITPA 94A allele seemed more prone to develop fever and liver toxicity in therapeutic protocols not individualized for TPMT[61].