NUDT15 and acute lymphoblastic leukemia: CPIC suggests to use the normal starting dose for NUDT15 normal metabolizers (e.g., NUDT15 *1/*1, MP 75 mg/m2/day in ALL) and a reduced one in intermediate metabolizers (e.g., NUDT15 *1/*3, MP 30%-80% normal starting dose) and poor metabolizers (e.g., NUDT15 *3/*3; MP 10 mg/m2/day in ALL)[36].