SETD2 and acute lymphoblastic leukemia: In addition to a role for aberrant histone methylation as a driver of leukemogenesis, targeted sequencing of epigenetic regulators in matched pairs of diagnostic and relapsed samples from pediatric patients with B-ALL revealed an enrichment of mutations in many of these regulators at the time of disease relapse, including a significant percentage of samples with mutations in the H3 lysine 36 (H3K36) trimethyltransferase SETD2[36].