Other examples are the E318K MITF variant, which as indicated above associates to melanoma, but was subsequently found to associate to renal cancer; the POLE and POLD1 germline variations, which are associated to colon cancer, however mutations in POLD1 also increase endometrial cancer risk; somatic mutations in BAP1, which were first identified in mesothelioma and uveal and cutaneous melanomas, were subsequently associated to renal cell cancer. This evidence concerns the gene POLD1 and renal carcinoma.