POLD1 and malignant colon neoplasm: Other examples are the E318K MITF variant, which as indicated above associates to melanoma, but was subsequently found to associate to renal cancer; the POLE and POLD1 germline variations, which are associated to colon cancer, however mutations in POLD1 also increase endometrial cancer risk; somatic mutations in BAP1, which were first identified in mesothelioma and uveal and cutaneous melanomas, were subsequently associated to renal cell cancer.