Knockdown of DNMT3A increased miR-199a-3p expression and attenuated the expression of DDR1 in ovarian cancer cells, while overexpression of miR-199a-3p impaired the migratory, invasive and tumorigenic capabilities of ovarian cancer cells as well as enhanced cisplatin resistance through inhibiting DDR1 expression. The gene discussed is DDR1; the disease is ovarian cancer.