FRZB and cancer: Main mechanisms by which Wnt signaling is dysregulated in cancer are mutations in β-catenin or other key pathway members, as well as hypermethylation and silencing of gatekeeper antagonists, such as the secreted frizzled-related protein (SFRP) and dickkopf (DKK), or overexpression of Wnt ligands or receptors, resulting in increased cancer cell proliferation and migration[48].