In vivo, pyrosequencing of ovarian cancer xenografts confirmed that SGI-110 caused both global (LINE1 repetitive sequences) and gene-specific hypomethylation, including the tumor suppressor gene Ras Association Domain Family 1 (RASSF1A), the assumed drivers of ovarian cancer cisplatin resistance and the zinc finger protein ZIC1, the differentiation-associated genes HOXA10 and HOXA11 and the transcription factor STAT5B, as well as the DNA mismatch repair gene MLH1. This evidence concerns the gene STAT5B and ovarian carcinoma.