Accordingly, minor alleles of rs17107315 in pancreatic secretory trypsin inhibitor (SPINK1), rs10436957 in chymotrypsin C (CTRC), and rs4409525 in Claudin-2 (CLDN2) all had significant associations with modulating the risk of ASNase-induced acute pancreatitis with directions and effects similar to the previously reported findings. This evidence concerns the gene CLDN2 and acute pancreatitis.