While the role of genetics in predisposition to acute recurrent and/or chronic pancreatitis of different etiologies has been the focus of many studies (PRSS1, PRSS2, SPINK1, CFTR, CLDN2, CAP1)[34,36-39], ASNase-related acute pancreatitis have only started emerging recently. Here, CLDN2 is linked to acute pancreatitis.