It is worth mentioning that in a study including 472 Japanese children with ALL who were treated on a protocol that included E. coli derived asparaginase, the authors followed a candidate-gene approach aimed at replicating the associations found with GRIA1 rs4958351, NFATC2 rs6021191, and ANSN rs3832526. Here, ASPG is linked to acute lymphoblastic leukemia.