In a work that tackled the PGx of ASNase through candidate-gene approach, by the association between SNPs in ASNS, ATF5 and ASS1 genes and ASNase induced allergy and pancreatitis was investigated in a discovery cohort of 285 ALL patients and a replication cohort of 248 patients who were treated according to Dana-Farber Cancer Institute ALL Consortium protocols. Here, ASNS is linked to acute lymphoblastic leukemia.