Early reports have indicated that lower exposure to ASNase during ALL treatment can result in an increased risk of relapse[52,53], which lead a research team to hypothesising that genetic polymorphisms of genes in asparagine pathway (i.e., ASNS, ATF5, and ASS1) can be associated with risk of event-free survival and relapse leading to a study that involved 318 Caucasian children with ALL and an independent replication cohort of 267 patients[18]. The gene discussed is ASS1; the disease is acute lymphoblastic leukemia.