Indeed, the associations of five of the polymorphisms (i.e., rs4958381, rs10070447, rs6890057, rs4958676, and rs6889909) in GRIA1 gene with HSRs were successfully validated within the same study in an independent replication cohort[25] and were later replicated in an independent Slovenian population of 146 pediatric ALL patients mainly treated according to one of Berlin-Frankfurt-Münster (BFM) treatment protocols[31]. This evidence concerns the gene GRIA1 and acute lymphoblastic leukemia.