Elevated SIRT1 deacetylase modulate the nuclear localization of FOXO1, an apoptosis associated EMT-TF and deacetylate the acetylated DNMT1 thus inhibition of SIRT1 enhance the DNMT1-mediated silencing of ER-α and CDH1 reflecting mesenchymal acquisition in MDA-MB-231 breast cancer cells[70]. This evidence concerns the gene ESR1 and breast carcinoma.