PTCH1 and breast cancer: Hh signaling ligands SHH, PTCH1 and SOX17 frequently methylated in breast cancer initiating cells and Hh effector proteins KIF7 and SUF7 deregulated through histone modifications and miRNA while GLI1 expression is elevated due to loss of KMT-SETD7 methylase in breast cancer cells thus drive the aberrant Hh as well as associated NF-κB signaling[39].