TREM2 is one of the major receptors of ApoE [22,23], the interactions between ApoE and TREM2 are important in the context of AD pathogenesis [24,25], and the TREM2–ApoE pathway has been reported to be a major regulator of the microglial functional phenotype in neurodegenerative diseases [26]. This evidence concerns the gene APOE and Alzheimer disease.