For the exploration of the regulatory mechanisms, we found that YTHDF2 repressed the mRNA stability of EPHB3 or TNFAIP3 in an m6A manner, implying that the YTHDF2/EPHB3/TNFAIP3 may be a novel regulation axis in TMZ resistance in GBM. Here, YTHDF2 is linked to glioblastoma.