The result suggested that the infection of LV‐YTHDF2 in T98G and LN229 cells reduced the luciferase activity of TNFAIP3‐WT (with m6A sites), and the infection of LV‐Sh‐YTHDF2 in T98G/TR and LN229/TR cells increased the luciferase activity of TNFAIP3‐WT. This evidence concerns the gene YTHDF2 and infection.