Although AD is primarily a disease of Th2 dysregulation, with IL‐4, IL‐13, IL‐31 and TSLP being key players, cytokines such as interferon (IFN)‐γ (Th1), IL‐17, IL‐22 (Th17) and IL‐33 are also involved.21 This evidence concerns the gene IL4 and Alzheimer disease.