Sirt1 is an NAD+-dependent type III histone deacetylase, which can catalyze the deacetylation of histone and non-histone lysine residues, and plays a vital role in regulating cell apoptosis (Zhang et al., 2017a), the occurrence and development of tumors (Alves-Fernandes & Jasiulionis, 2019), metabolic diseases (Yu et al., 2018) and anti-aging (Xu et al., 2020). The gene discussed is SIRT1; the disease is metabolic disease.