As an NAD+ dependent class III deacetylase, Sirt1 plays vital physiological function in a variety of diseases such as tumors and metabolic diseases (Alves-Fernandes & Jasiulionis, 2019; Yu et al., 2018), including liver fibrosis (Ramirez et al., 2017). This evidence concerns the gene SIRT1 and Hepatic fibrosis.