VEGFA and neoplasm: Some of the more well described targets are SPRED1, p85β, and PI3KR2 governing vascular integrity[10,27], VEGF-A regulating AKT-pathway signaling[28], CXCR4 and IRS-1 involved in CRC cell proliferation and migration[29,30], and KRAS impacting on the viability of the mutated tumor cells[31].