PIK3CA and neoplasm: Three major types of molecular alterations have been reported to be at the origin of hepatocarcinogenesis: i) Aberrant cell proliferation and survival due to a constitutive activation of signaling pathways, such as EGFR-Ras-MAPK, PI3K-AKT-mTOR, HGF/MET, Wnt-β-catenin and others; ii) Deregulation of proapoptotic machinery elements, such as p53 and Bcl2; and iii) Stimulation of neo-angiogenesis, which is crucial for tumor development[2].