EGFR and non-small cell lung carcinoma: Recent studies have demonstrated that gefitinib and erlotinib - a specific inhibitor of EGFR tyrosine kinase (first-generation EGFR-TKIs) - has been shown to repress the activation of EGFR signaling required for cell survival and proliferation in the treatments of non-small cell lung cancer (NSCLC) cell lines[3-5].