CASP1 and acute lymphoblastic leukemia: Another pathway that regulates GR levels is the NLRP3-CASP1 inflammasome, and increased levels of NLRP3 and CASP1 expression in GC-resistant and relapsed ALL samples due to promoter hypomethylation of these genes promote GR cleavage and GC resistance [Figure 2 and Table 1][94].