FOXO3a is a critical regulator of BIM expression[117,118], and inhibition of the FOXO3a/BIM axis is observed in GC-resistant T-ALL[119], but also epigenetic silencing of BIM(BCL2L11) expression is detected in pediatric ALL poor prednisone responders[120]. This evidence concerns the gene BCL2L11 and acute lymphoblastic leukemia.