Activation of the PI3K pathway may also result through autocrine and paracrine release from cytokines in lymphoid tumors, and LCK hyperactivation in GC-resistant T-ALL results in upregulation of calcineurin/nuclear factor of activated T cells signaling, which triggers interleukin-4 (IL-4) overexpression[156]. Here, LCK is linked to acute lymphoblastic leukemia.