The mechanism which by HOXD-AS1 is able to regulate the sensitivity of prostate cancer cells to paclitaxel is by HOXD-AS1 binding to WDR5 leading to activation of proteins PLK1, AURKA, FOXM1, CDC25c, UBE2C, CCNA2, and CCNB1 which are critical proteins in the mitosis, cell cycle regulation, microtubule stabilization, and androgen receptor signaling pathways[30]. The gene discussed is HAGLR; the disease is prostate carcinoma.