EPHX1 and lung carcinoma: Furthermore, the NRF2 dependent increase in carbonyl reductases leads to Doxorubicin resistance by reduction of the drug in leukemia and gastric cancer[149,150]; microsomal epoxide hydrolase acts through hydrolysis and is found to be overexpressed in gemcitabine resistant lung cancer cells[151]; Aldo-keto reductases lead to the resistance of lung cancer cells to Daunorubicin and Lidarubicin[152].