TGFB1 and neoplasm: Combination therapies proposed to alter the interaction between the immune system and tumor include agents such as cyclophosphamide or oxaliplatin to increase the priming of effector T cells, PI3Kγ to inhibit myeloid suppressor cells, CSF-1R inhibitors to downregulate tumor associated macrophages and TGF-β inibitors to downregulate Tregs[35,139-145,232-236].