In fact, doxorubicin resistance in melanoma cells was associated with expression of ABCB8, a member of ABC transporter family expressed on the inner mitochondrial membrane: ABCB8 overexpression provided doxorubicin resistance protecting mtDNA from damage, while its knockdown resensitized cells to doxorubicin[87]. The gene discussed is ABCB8; the disease is melanoma.