TLK1 and posterior cortical atrophy: Furthermore, ADT increases pMK5 S354 level in LNCaP cells, and this pMK5 protein is progressively increased in tumors of higher grades and nodal metastatic scores analyzed from TRAMP mice prostate tissue and human PCa TMA, suggesting that the TLK1>MK5 signaling may be associated with increased aggressiveness of PCa.