CD8A and neoplasm: Interestingly, after immunohistochemical staining of the primary tumor and metastases samples with HPD, Barham et al. [34] showed that the tumor infiltrating lymphocyte (TIL) number was not necessarily correlated with ICI response, as levels of granzyme B and TIA-1 of infiltrated CD8+ T cells were mostly negative, indicating that these were inflammatory T cells which cause tumor drug resistance and myocarditis.