Lastly, evaluating the multikinase inhibitor regorafenib and the BRAF V600 inhibitor vemurafenib activity on these cell lines, a variable sensitivity to regorafenib was exerted and specifically one of these CTC lines emerged to be responsive to vemurafenib, although this BRAF V600 inhibitor demonstrated a scarce efficacy in BRAF-mutated colorectal cancer patients[21] [Table 2]. Here, BRAF is linked to colorectal cancer.