Platelets are actively involved in CTCs’ protection during their transit into the bloodstream in many ways, for example, defending them from mechanical stress, as well as cancer-associated fibroblasts, and inducing resistance from anoikis, which is regulated by the YAP pathway, determining RhoA-(myosin phosphatase targeting subunit 1) and MYPT1-protein phosphatase (PP1)-mediated Yes-associated protein 1 (YAP1) dephosphorylation and nuclear translocation[35,36]. The gene discussed is PPP1R12A; the disease is cancer.